Honolulu enjoys the most extensive health insurance coverage of any major American city, with only 5.25 percent of its residents without coverage, according to U.S. Census Bureau data.

The American Community Survey (ACS) is an annual program designed to generate data during the years between the Census Bureau's head counts every 10 years. The bureau has been releasing 2008 ACS data in stages during the past month.

The data covered the 70 cities with civilian populations of 250,000 or more. The following are the 10 major U.S. cities with the lowest percentage of residents without health insurance and the 10 cities with the highest percentages. These rankings are limited to the cities proper, not their metropolitan areas.

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